BDR Research Highlights
The top image shows how tactile sensation is generated by the skin. Hair follicle stem cells (blue), which are important for hair shaft generation, secrete extracellular matrix proteins (green) that guide the connections of the neural network (red) to the skin, helping the skin to sense mechanical stimulation.
Image: Lab for Tissue Microenvironment
Scientists lay foundation for single-cell level understanding of DNA replication
Lab for Developmental Epigenetics developed a new method to examine DNA replication in individual cells, which revealed stability of DNA replication program and higher-order chromatin structure in mammalian cells.
Two inhibitory molecules ensure that cells move full steam ahead
Lab for Cell Signaling Dynamics reveal cells move in a single direction due to two mutually inhibiting molecules on their surfaces.
Microtubule and kinesin interactions send cellular cargo to the right destination
The molecular mechanism that ensures cellular cargo is transported along the right track has been identified by Lab for Cell Polarity Regulation.
Evolution of the inner ear: insights from jawless fish
Lab for Evolutionary Morphology has described for the first time the development of the hagfish inner ear. The study provides a new story for inner ear evolution that began with the last common ancestor of modern vertebrates.
Creating a functional salivary gland organoid
Lab for Organ Regeneration succeeded in growing three-dimensional salivary gland tissue that, when implanted into mice, produced saliva-like normal glands.
Gene Fam60a found to play a key role in the developing embryo
Lab for Organismal Patterning revealed that healthy development of an embryo depends on a protein that regulates the DNA of stem cells
Getting a grip on the slow but unique evolution of sharks
By decoding the whole genomes of three shark species and comparing them with those of other vertebrate species, Lab for Phyloinformatics solved molecular riddles of their unique life histories and evolutionary paths.
Signaling relays offer an efficient alternative for coordinating embryonic development
Live imaging analysis of developing fly embryos by Lab for Morphogenetic Signaling reveal that a surprising ‘switch’-based signaling mechanism governs tissue formation.
Two essential genes that regulate how much REM sleep we experience
Rapid eye movement (REM) sleep is a mysterious stage of sleep in which animals dream. Lab for Synthetic Biology has identified a pair of genes that regulate how much REM sleep an animal experiences.
Mechanism stabilizing chromosome pairs during meiosis identified
Lab for Chromosome Segregation show that modification with a protein called SUMO helps maintain proper chromosomal organization in newly produced egg cells.
New single-cell RNA sequencing methods could lead to better regenerative therapies
Lab for Bioinformatics Research developed an improved method for analyzing expression of genes by single cells with the potential to enhance regenerative medicine therapy as well as disease research.